Endocrine Abstracts

Objective: To investigate the frequencies of three paraoxonase (PON)1 polymorphisms in Greek polycystic ovary syndrome (PCOS) and non-PCOS women, and their genotypes in association with hyperandrogenemia and insulin resistance.Design: Case–control genetic association study.Patients: PCOS cases (NIH criteria) and 112 controls.Main outcome measure: Genotyping of the c.−108C>T (PON1-108), the c.16...

Oxidative stress in humans has been associated with obesity. Puberty is a maturation period characterized mainly by changes of the GH and the gonadotrophin hormones secretion. To investigate the possible association of the GH and the hypothalamic–pituitary–gonadal (HPG) axes before and during early puberty, with the pro- and anti-oxidation mechanisms 76 healthy, pre-pubertal normal weight (n=28), pre-pubertal obese (n=11), early pubertal normal weig...

Introduction: Denosumab, a human monoclonal antibody that inhibits activation of osteoclasts provides sustained suppression of bone turnover in osteolytic bone disease. Denosumab has rarely been associated with late hypercalcaemia following therapeutic administration for bone tumours in children, bone metastases in adults and in children with Osteogenesis Imperfecta Type VI.Case report: A male child of Indian origin was referred for advice to GOSH from a...